Marie-Louise Ricketts

Photo of Marie-Louise Ricketts

Assistant Professor

Department of Agriculture, Nutrition and Veterinary Sciences
University of Nevada/Mail Stop 202
1664 N. Virginia Street
Reno,  Nevada   89557

Office: (775) 784-6442
Fax: 784-6449

Building: Max Fleischmann Agriculture,  Office 105

Download Electronic Business Card OR vCard

B.S., Sheffield Hallam University, UK, 1991
Ph.D., Department of Medicine, University of Birmingham, England, UK, 1998


My research program is in the area of molecular nutrition and endocrinology. My work focuses on understanding the molecular mechanisms underlying metabolic effects of bioactive dietary constituents/natural products, with an emphasis on the role played by nuclear hormone receptors (NHRs).


Downing LE, Ferguson BS, Rodriguez K, Ricketts ML. 2016, A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparalpha phosphorylation and target-gene expression., Molecular nutrition & food research 2016. DOI: 10.1002/mnfr.201600347
Heidker, R. M., Caiozzi, G. C., Ricketts, M.-L. 2016, Dietary procyanidins selectively modulate intestinal farnesoid X receptor-regulated gene expression to alter enterohepatic bile acid recirculation: elucidation of a novel mechanism to reduce triglyceridemia., Molecular Nutrition and Food Research. 2016, 00, 1–10
Heidker RM, Caiozzi GC, Ricketts M-L 2016, Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver, PLoS ONE 11(4): e0154305. doi:10.1371/ journal.pone.0154305
Downing, L. E., Heidker, R. M., Caiozzi, G. C., Wong, B. S., Rodriguez, K., Del Rey, F., Ricketts, M.-L. (2015) 2015, A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis., Plos One, 10(10), 19.
Heidker, R., Caiozzi, G., Ricketts, M.-L 2015, Co-administration of a Grape Seed Procyanidin Extract and the Bile Acid Sequestrant, Cholestyramine, Results in Beneficial Metabolic Alterations, Including Decreased Triglyceride Levels, The FASEB Journal vol. 29 no. 1 Supplement 271.5
Caiozzi, G., Wong, B., Ricketts, M.-L. 2012, Dietary modification of metabolic pathways via nuclear hormone receptors, Cell Biochemistry and Function 30:7, p531–551
J.M.Del Bas*, M.L.Ricketts*, M.Vaqué, E.Sala, H.Quesada, A.Ardevol, A.M.J.Salvadó, M.Blay, L.Arola, D.D.Moore, G. Pujadas, J. Fernandez-Larrea, C.Bladé 2009, Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner., Molecular Nutrition and Food Research 2009 53(7):805-14
J.M.Del Bas, M.L.Ricketts, I.Baiges, H.Quesada, A.Ardevol, M.J.Salvadó, G.Pujadas, M.Blay, L.Arola, C.Bladé, D.D.Moore, J. Fernandez-Larrea 2008, Dietary procyanidins lower triglyceride levels signalling through the nuclear receptor Small heterodimer partner., Molecular Nutrition and Food Research 52(10):1172-81.
M.L.Ricketts*, M.V.Boekschoten, A.J.Kreeft, G.J.Hooiveld, C.J.Moen, M.Muller, R.R.Frants, S.Kasanmoentalib, S.M.Post, H.M.Princen, J.G.Porter, M.B.Katan, M.H.Hofker & D.D.Moore, 2007, The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane x receptors., Molecular Endocrinology. 21 (7): 1603-1616 (Epub: April 24th 2007)